The latest Circus of the Spineless is up at Words & Pictures, exploring mountain mollusks, ancient spiders, sex and cannibalism, exploding jellies and other wonders of the invertebrate world.Read the 11th edition here.
The latest Circus of the Spineless is up at Words & Pictures, exploring mountain mollusks, ancient spiders, sex and cannibalism, exploding jellies and other wonders of the invertebrate world.The genetic code specifies all the proteins that a cell makes. The second code, superimposed on the first, sets the placement of the nucleosomes, miniature protein spools around which the DNA is looped. The spools both protect and control access to the DNA itself.The discovery, if confirmed, could open new insights into the higher order control of the genes, like the critical but still mysterious process by which each type of human cell is allowed to activate the genes it needs but cannot access the genes used by other types of cell.
Imagine this: fundamentally, our DNA is spun around little protein spools called histones. These histones provide a structure for DNA and assist in gene regulation, or the process of turning genes on and off. Genes, obviously, cause development.
There are two histone sites where the methyl-marking (methylation) occurs; the K4 site and the K27 site. At the K27 site, the DNA is bound very tightly to the histone complex, not allowing any strands to become available for transcription (expression of DNA into protein). These sites are marked in adults.
At the K4 site, the strands are loosely bound, more accessible. K4 sites are marked in young, undifferentiated cells, like embryonic stem cells.
What this says, in a nutshell, is that they have found the areas where gene expression is a go (marked K4 region, in young cells) and where it is shut down (K27, in adults).
Certain genes do not have to be "turned on" when we are fully grown - especially genes that direct limb or organ growth - and the marked K27 site prevents that area of DNA to be accessed.
However, the K4 site would need to marked in the blastocyst and the DNA made available in order to start the differentiation process, so the cells could be directed into whatever is needed: liver cells, muscle tissue, bone, neurons, etc.
Despite common belief to the opposite, the ideology of environmentalism is not concerned with improving man's life on earth. If it were, it would not oppose but champion industrial progress--luxury homes, dams, highways, bioengineering, food irradiation, etc.--and the individuals who create it.Ghate places all environmentalists (apparently including conservation biologists and ecologists) in the same boat, assuming that all accepting that title are no better than self-destructive anarchists with murderous intentions, wishing for the day that industrialized society collapses. While I was reading this essay, I kept waiting for some distinction to be made between the criminals from ELF that were apprehended and prosecuted and the conservationists concerned with protecting our wild areas and maintaining biodiversity through sound science and economics. Ghate acts like human beings aren't inhabitants of the biosphere.Environmentalism instead champions wilderness (including wild animals). On this premise, science and technology are irredeemably evil. If the supreme value is a world untouched by human hands, then in logic man and industry are destroyers of value, to be eliminated by force if necessary.
Committed environmentalists openly voice this hatred of man and industry. The founder of Green Peace reflects: "I got the impression that instead of going out to shoot birds, I should go out and shoot kids who shoot birds." A biologist with the U.S. National Park Services states: "Until such time as Homo sapiens should decide to return to nature, some of us can only hope for the right virus to come along." The head of the 1992 Earth Summit wonders: "Isn't the only hope for the planet that the industrialized civilizations collapse? Isn't it our responsibility to bring that about?"
Environmental terrorism is a consistent expression of environmentalism's worship of wilderness. By making the preservation of untouched nature the ideal, environmentalism necessarily makes man, who survives by exploiting nature, the enemy.
If we value our lives, we must never make common cause with environmentalism, no matter how appealing a particular environmentalist project may seem. We must fight not only against particular environmental terrorists but also against the ideology that inspires them. But even more important, we must fight for rational values: man's life and industrial civilization.

Only about one bone in a billion, it is thought, ever becomes fossilized. If that is so, it means that the complete fossil legacy of all the Americans alive today - that's 270 million people with 206 bones each - will only be about fifty bones, one quarter of a complete skeleton.Needless to say, invertebrate paleontologists are having a heck of a time piecing things together from such a paltry fossil record. But that doesn't mean there's no evidence.
Gilbert White’s Selborne Journal: Friday, 30 April 1784: 29 7/10; 54; NE, E. Grey, sun, summer-like. Cucumbers set, & swell. Polyanths begin to blow well. Tulips shoot, & are strong. Sowed a pint of scarlet kidney-beans. Goose-berry bushes leaf: quick-sets still naked. Pile-wort in full bloom. Rain in April..3 inch: 92 hund:VK: By quick-set, GW means the new slips of hawthorn that were laid to make a hedge.
*** I often try to explain why my wife and I live where we do. In the country, in nature, where we can raise pigs and chickens — those are the phrases I end up using. But it really comes down to living as close to wildness as we can. I realize that now. What makes it easier is that so many wild creatures don’t mind living near us — so near that we hardly think of them as wild any more. The grace of wildness changes somehow when it becomes familiar, when you know it as well as we know the wild turkeys and the downy woodpeckers.The other morning, I looked out the south window to see if the flag had dropped on our rural mailbox. I saw a fox just beyond it, standing in the downfall of last year’s goldenrod. The fox paused long enough for me to get the binoculars, and then it moved off the flat to the base of a rock outcrop, part of the orbit she uses to approach our poultry. Something else moved with her. Three, perhaps four young kits were following her.
She turned and led them back to the lip of the den, where they crowded around her. She bent down and licked one of them. They were only a few pounds each, thick with soft, mottled brown fur. In another week the grass will be tall enough to hide them. A week earlier, and they would have been too young to leave the den. The vixen slipped up the hill again, and her young did not reappear.
The den is only as far from the mailbox as our house is, dug into the sunken foundation of a long-vanished outbuilding. I am only a few steps away from those kits whenever I gather the mail. A couple of weeks ago I walked over to that old foundation to see if there were any fox signs, but it is far easier to trace the vixen by her cries in the night — circling around our pasture — than by footprints during the day. I wasn’t even sure the den was really there. Now I know. I won’t go back again until midsummer, but I cannot stop watching.
When I say the grace of wildness, what I mean is its autonomy, its self-possession, the fact that it has nothing to do with us. The grace is in the separation, the distance, the sense of a self-sustaining way of life. That vixen may rely on us for a duck or a chicken now and then, and to keep the woodland from closing in. How she chose to den so close to us is beyond me. The answer is probably as simple as an available hole. But our only choice is to leave her alone, to give her enough room to raise the next generation.

Rather than trying to simply ring-fence what wildlife remains, conservationists need to be restoring whole ecologies to something of their former glory, says Josh Donlan, an ecologist at Cornell University (Ithaca, New York, United States). Last year, he and a long list of high-profile conservation biologists penned a controversial commentary in Nature in which they laid out the case for rewilding North America seeding the continent with suitable stand-ins for species that went extinct thousands of years ago [2].Optimistic is an appropriate term. I can see the attraction of a program like this; conservation biologists are often ignored, and seem to be relegated to passive measures of protection. This seeding method is an active approach, where they can use their knowledge to manipulate ecological systems in order to save certain environments.Donlan's world would see carefully chosen slivers of North America grazed by giant tortoises, horses, and camels; the stamping ground of elephants in place of five species of mammoth; and African lions in lieu of the extinct American lion that once stalked the continent.
The benefits, they argued, are obvious. It would restore ecological processes that have gone by the wayside, mend broken evolutionary relationships, create a back-up population of some of the planet's most endangered species, and raise huge awareness for the conservation cause. The obstacles are substantial and the risks are not trivial, but we can no longer accept a hands-off approach to wilderness preservation, they wrote of their optimistic vision.